Desmopressin is a prescription drug that is similar to a hormone found naturally in your body. It is used to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions, allowing you to sleep through the night without awakening to urinate. Desmopressin is also used to treat specific types of diabetes insipidus and conditions after head injury or pituitary surgery.

How do I use and store Desmopressin?

Desmopressin comes in a liquid form that is administered into the nose (a nasal spray). It is used twice a day (every morning and evening). For bed wetting, it is used every evening at bedtime. Use Desmopressin exactly as directed. If you have any difficulty understanding the label instructions contact your doctor for further explanation. Do not use more or less of it or more often than your doctor prescribes.

To use the nasal spray, first clear your nasal passages by gently blowing your nose. Insert the sprayer into a nostril. Sniff as you squeeze the sprayer once. To prevent mucus from entering the sprayer, release your grip after you remove the sprayer from your nose. Gently sniff two or three more times.

Do not allow the liquid to run into your mouth. Follow the directions carefully; if you have difficulty using the drug or giving it to a child, ask your doctor or pharmacist for advice.

Keep Desmopressin in the container it came in, tightly closed, and out of reach of children. Store it in the refrigerator; do not freeze. The nasal bottle contains 25 or 50 doses. Do not put any leftover medication into another bottle. Throw away any Desmopressin that is outdated or no longer needed.

What should I know before using Desmopressin?

Before using desmopressin tell your doctor:

• if you are allergic to Desmopressin or any other drugs.
• what prescription and nonprescription drugs you are taking, especially carbamazepine (Tegretol), chlorpropamide (Diabinese), clofibrate (Atromid-S), demeclocycline (Declomycin), epinephrine, lithium, and vitamins.
• if you have or have ever had heart disease, high blood pressure, coronary artery disease, nose or sinus problems or surgery, or cystic fibrosis.
• if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using Desmopressin, call your doctor.

Desmopressin may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. Alcohol can add to the drowsiness caused by this drug.

If Desmopressin loses its effectiveness (if urination increases or you wake up earlier than usual to urinate), call your doctor. Your dose may need to be changed.

Does Desmopressin have any side effects?

Desmopressin may cause side effects. If you experience any of the following symptoms, call your doctor immediately:

• upset stomach
• headache
• stuffy or runny nose
• reddening of the skin
• stomach cramps
• pain in the external genital area (in women)

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